Reaction Details |
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Target | Disintegrin and metalloproteinase domain-containing protein 10 |
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Ligand | BDBM50301107 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_598554 (CHEMBL1043546) |
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IC50 | 11±n/a nM |
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Citation | Li, YL; Shi, E; Burns, D; Li, Y; Covington, MB; Pan, M; Scherle, P; Friedman, S; Metcalf, B; Yao, W Discovery of novel selective HER-2 sheddase inhibitors through optimization of P1 moiety. Bioorg Med Chem Lett19:5037-42 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Disintegrin and metalloproteinase domain-containing protein 10 |
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Name: | Disintegrin and metalloproteinase domain-containing protein 10 |
Synonyms: | ADA10_HUMAN | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) | KUZ | MADM |
Type: | Enzyme |
Mol. Mass.: | 84160.93 |
Organism: | Homo sapiens (Human) |
Description: | O14672 |
Residue: | 748 |
Sequence: | MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
KRRRPPQPIQQPQRQRPRESYQMGHMRR
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BDBM50301107 |
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n/a |
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Name | BDBM50301107 |
Synonyms: | CHEMBL572301 | isopropyl-(5S,6S)-5-(hydroxycarbamoyl)-6-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidin-3-yl(methyl)carbamate |
Type | Small organic molecule |
Emp. Form. | C23H32N4O5 |
Mol. Mass. | 444.524 |
SMILES | CC(C)OC(=O)N(C)C1CN[C@@H]([C@H](C1)C(=O)NO)C(=O)N1CCC(=CC1)c1ccccc1 |r,c:24| |
Structure |
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