| Reaction Details |
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 | Report a problem with these data |
| Target | Disintegrin and metalloproteinase domain-containing protein 10 |
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| Ligand | BDBM50227986 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_598554 (CHEMBL1043546) |
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| IC50 | 323±n/a nM |
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| Citation |  Li, YL; Shi, E; Burns, D; Li, Y; Covington, MB; Pan, M; Scherle, P; Friedman, S; Metcalf, B; Yao, W Discovery of novel selective HER-2 sheddase inhibitors through optimization of P1 moiety. Bioorg Med Chem Lett19:5037-42 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Disintegrin and metalloproteinase domain-containing protein 10 |
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| Name: | Disintegrin and metalloproteinase domain-containing protein 10 |
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| Synonyms: | ADA10_HUMAN | ADAM10 | Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) | KUZ | MADM |
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| Type: | Enzyme |
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| Mol. Mass.: | 84160.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14672 |
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| Residue: | 748 |
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| Sequence: | MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFL
RLDFHAHGRHFNLRMKRDTSLFSDEFKVETSNKVLDYDTSHIYTGHIYGEEGSFSHGSVI
DGRFEGFIQTRGGTFYVEPAERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFE
RMRKYQMTGVEEVTQIPQEEHAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE
AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
DECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRDDSDCAREGICNGFT
ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVCCMK
KMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
IFSPELYENIAEWIVAHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
KRRRPPQPIQQPQRQRPRESYQMGHMRR
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| BDBM50227986 |
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| n/a |
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| Name | BDBM50227986 |
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| Synonyms: | (6S,7S)-6-(3-phenyl-pyrrolidine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide | (6S,7S)-N-hydroxy-6-(3-phenylpyrrolidine-1-carbonyl)-5-azaspiro[2.5]octane-7-carboxamide | CHEMBL252246 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H25N3O3 |
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| Mol. Mass. | 343.4201 |
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| SMILES | ONC(=O)[C@H]1CC2(CC2)CN[C@@H]1C(=O)N1CCC(C1)c1ccccc1 |r| |
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| Structure | 
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