Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50108653 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_599822 (CHEMBL1042781) |
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Ki | 1.3±n/a nM |
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Citation | Jasper, A; Schepmann, D; Lehmkuhl, K; Vela, JM; Buschmann, H; Holenz, J; Wünsch, B Synthesis of sigma receptor ligands with unsymmetrical spiro connection of the piperidine moiety. Eur J Med Chem44:4306-14 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein |
Type: | Protein |
Mol. Mass.: | 25307.17 |
Organism: | Cavia porcellus (Guinea pig) |
Description: | Q60492 |
Residue: | 223 |
Sequence: | MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
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BDBM50108653 |
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n/a |
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Name | BDBM50108653 |
Synonyms: | 1'-benzyl-3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-(hexahydropyridine)] | 1'-benzyl-3-methoxyspiro[isochroman-1,4'-piperidine] | CHEMBL141209 |
Type | Small organic molecule |
Emp. Form. | C21H25NO2 |
Mol. Mass. | 323.4287 |
SMILES | COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1 |
Structure |
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