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TargetTranscription factor HES-1
LigandBDBM50378455
Substrate/Competitorn/a
Meas. Tech.ChEMBL_598858
IC50 16500±n/a nM
Citation Arai MAMasada AOhtsuka TKageyama RIshibashi M The first Hes1 dimer inhibitors from natural products. Bioorg Med Chem Lett 19:5778-81 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Transcription factor HES-1
Name:Transcription factor HES-1
Synonyms:Hairy and enhancer of split 1
Type:PROTEIN
Mol. Mass.:29762.25
Organism:Mus musculus
Description:ChEMBL_598858
Residue:282
Sequence:
MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTL
ILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNE
VTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQAHPALQAPPPPPPSGPAGPQHA
PFAPPPPPLVPIPGGAAPPPGSAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAF
AHSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTSDSMWRPWRN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50378455
n/a
NameBDBM50378455
Synonyms:LYCOGARUBIN B
TypeSmall organic molecule
Emp. Form.C24H19N3O5
Mol. Mass.429.4248
SMILESCOC(=O)c1[nH]c(C(=O)OC)c(-c2c[nH]c3ccc(O)cc23)c1-c1c[nH]c2ccccc12 |(7.11,-6.42,;8.45,-7.17,;9.78,-6.38,;9.75,-4.84,;11.12,-7.13,;12.37,-6.21,;13.62,-7.11,;14.94,-6.31,;14.9,-4.77,;16.29,-7.05,;17.6,-6.24,;13.14,-8.58,;13.64,-10.04,;12.75,-11.29,;13.68,-12.53,;15.13,-12.02,;16.46,-12.77,;17.79,-11.98,;17.76,-10.44,;19.08,-9.65,;16.42,-9.7,;15.11,-10.49,;11.6,-8.6,;11.13,-10.06,;12.04,-11.31,;11.13,-12.56,;9.67,-12.08,;8.34,-12.85,;7,-12.09,;6.99,-10.54,;8.33,-9.77,;9.66,-10.54,)|
Structure
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