Ki Summary

Reaction Details

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Target

Transcription factor HES-1

Ligand

BDBM50378455

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_598858 (CHEMBL1044690)

IC50

16500±n/a nM

Citation

Arai, MA; Masada, A; Ohtsuka, T; Kageyama, R; Ishibashi, M The first Hes1 dimer inhibitors from natural products. Bioorg Med Chem Lett19:5778-81 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Transcription factor HES-1

Name:

Transcription factor HES-1

Synonyms:

HES1_MOUSE | Hairy and enhancer of split 1 | Hes-1 | Hes1

Type:

PROTEIN

Mol. Mass.:

29762.25

Organism:

Mus musculus

Description:

ChEMBL_598858

Residue:

282

Sequence:

MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTL
ILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNE
VTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQAHPALQAPPPPPPSGPAGPQHA
PFAPPPPPLVPIPGGAAPPPGSAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAF
AHSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTSDSMWRPWRN

BDBM50378455

n/a

Name

BDBM50378455

Synonyms:

LYCOGARUBIN B

Type

Small organic molecule

Emp. Form.

C24H19N3O5

Mol. Mass.

429.4248

SMILES

COC(=O)c1[nH]c(C(=O)OC)c(-c2c[nH]c3ccc(O)cc23)c1-c1c[nH]c2ccccc12 |(7.11,-6.42,;8.45,-7.17,;9.78,-6.38,;9.75,-4.84,;11.12,-7.13,;12.37,-6.21,;13.62,-7.11,;14.94,-6.31,;14.9,-4.77,;16.29,-7.05,;17.6,-6.24,;13.14,-8.58,;13.64,-10.04,;12.75,-11.29,;13.68,-12.53,;15.13,-12.02,;16.46,-12.77,;17.79,-11.98,;17.76,-10.44,;19.08,-9.65,;16.42,-9.7,;15.11,-10.49,;11.6,-8.6,;11.13,-10.06,;12.04,-11.31,;11.13,-12.56,;9.67,-12.08,;8.34,-12.85,;7,-12.09,;6.99,-10.54,;8.33,-9.77,;9.66,-10.54,)|

Structure