| Reaction Details |
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 | Report a problem with these data |
| Target | Proton-coupled folate transporter |
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| Ligand | BDBM50306577 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_610923 (CHEMBL1067646) |
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| pH | 6.8±n/a |
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| Ki | 2230±n/a nM |
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| Comments | extracted |
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| Citation |  Wang, L; Cherian, C; Desmoulin, SK; Polin, L; Deng, Y; Wu, J; Hou, Z; White, K; Kushner, J; Matherly, LH; Gangjee, A Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry. J Med Chem53:1306-18 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proton-coupled folate transporter |
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| Name: | Proton-coupled folate transporter |
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| Synonyms: | G21 | HCP1 | Heme carrier protein 1 | PCFT | PCFT/HCP1 | PCFT_HUMAN | SLC46A1 | Solute carrier family 46 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49782.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1469597 |
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| Residue: | 459 |
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| Sequence: | MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGT
RQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLA
SLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFR
MALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKST
RLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWD
SKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFT
GYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNF
MKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP
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| BDBM50306577 |
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| n/a |
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| Name | BDBM50306577 |
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| Synonyms: | (S)-2-({5-[5-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)-pentyl]-thiophene-2-carbonyl}-amino)-pentanedioicAcid | CHEMBL605580 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25N5O6S |
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| Mol. Mass. | 475.518 |
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| SMILES | Nc1nc2[nH]c(CCCCCc3ccc(s3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cc2c(=O)[nH]1 |r| |
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| Structure | 
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