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TargetGalanin receptor type 1
LigandBDBM50307253
Substrate/Competitorn/a
Meas. Tech.ChEMBL_610344 (CHEMBL1072076)
Ki 51±n/a nM
Citation Robertson, CRScholl, EAPruess, THGreen, BRWhite, HSBulaj, G Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic delivery. J Med Chem53:1871-5 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Galanin receptor type 1
Name:Galanin receptor type 1
Synonyms:GAL1-R | GALNR | GALNR1 | GALR1 | GALR1_HUMAN | Galanin R1 | Galanin receptor 1 | Galanin receptor type 1
Type:Enzyme Catalytic Domain
Mol. Mass.:38976.60
Organism:Homo sapiens (Human)
Description:Galanin R1 GALR1 HUMAN::P47211
Residue:349
Sequence:
MELAVGNLSEGNASWPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLAR
SKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSML
VSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPR
ASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEA
SKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNP
IIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKESKSRIDTPPSTNCTHV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50307253
n/a
NameBDBM50307253
Synonyms:CHEMBL592415 | WTLNSAGYLLGPHAVGNHPSFSDKNGLTS-CONH2
TypeSmall organic molecule
Emp. Form.C137H207N41O42
Mol. Mass.3100.359
SMILESCC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(O)=O |r,wU:63.64,51.56,37.40,8.12,92.95,107.111,118.122,136.141,153.158,170.176,187.193,199.205,214.220,wD:59.60,75.79,43.48,32.33,16.25,4.4,88.92,102.107,126.130,147.152,164.170,178.184,207.213,208.216,(42.1,-65.81,;41.31,-64.49,;42.06,-63.14,;39.77,-64.51,;38.98,-63.18,;37.44,-63.2,;36.67,-64.54,;37.47,-65.87,;35.13,-64.56,;34.34,-63.22,;35.1,-61.88,;34.32,-60.55,;36.64,-61.87,;34.38,-65.91,;32.83,-65.91,;32.05,-64.59,;32.08,-67.27,;32.86,-68.6,;34.41,-68.58,;35.16,-67.23,;36.69,-67.22,;37.49,-68.54,;39.03,-68.52,;36.72,-69.88,;35.19,-69.9,;30.54,-67.28,;29.78,-68.62,;30.58,-69.95,;28.24,-68.64,;27.47,-69.98,;25.93,-70,;25.14,-68.67,;25.19,-71.35,;25.97,-72.68,;23.63,-71.36,;22.88,-72.71,;23.67,-74.04,;21.34,-72.73,;20.55,-71.39,;21.3,-70.06,;20.58,-74.07,;19.03,-74.09,;18.24,-72.76,;18.28,-75.44,;19.06,-76.76,;20.6,-76.74,;21.36,-75.4,;21.4,-78.07,;16.74,-75.44,;15.97,-76.8,;16.77,-78.11,;14.43,-76.8,;13.65,-75.48,;14.41,-74.14,;13.62,-72.81,;15.95,-74.12,;13.67,-78.15,;12.12,-78.18,;11.35,-76.84,;11.38,-79.52,;9.84,-79.53,;9.07,-80.88,;9.86,-82.2,;7.53,-80.9,;6.77,-82.24,;6.75,-79.57,;7.5,-78.23,;9.04,-78.04,;9.34,-76.54,;8,-75.79,;7.66,-74.29,;6.18,-73.82,;5.05,-74.86,;5.4,-76.36,;6.85,-76.82,;12.16,-80.84,;11.4,-82.18,;13.7,-80.83,;39.73,-61.84,;38.95,-60.5,;41.27,-61.81,;42.03,-60.47,;43.57,-60.45,;44.36,-61.77,;44.33,-59.11,;45.97,-59.47,;46.84,-58.04,;45.74,-56.77,;44.43,-57.6,;43.09,-56.83,;41.75,-57.6,;43.09,-55.29,;41.76,-54.52,;40.44,-55.29,;39.08,-54.51,;38.95,-52.96,;37.43,-52.64,;36.66,-53.95,;37.69,-55.11,;41.76,-52.96,;43.12,-52.19,;40.44,-52.2,;40.44,-50.66,;41.79,-49.86,;39.11,-49.89,;37.78,-50.66,;39.11,-48.32,;37.78,-47.57,;36.47,-48.32,;35.12,-47.55,;36.47,-49.85,;37.78,-46.02,;39.14,-45.22,;36.47,-45.25,;36.47,-43.68,;35.15,-42.92,;33.83,-43.68,;35.15,-41.37,;33.83,-40.6,;32.5,-41.37,;31.15,-40.58,;31.15,-39.02,;29.83,-41.33,;33.83,-39.04,;35.17,-38.25,;32.5,-38.28,;32.5,-36.71,;33.85,-35.93,;33.85,-34.41,;32.63,-33.49,;33.12,-32.04,;34.66,-32.05,;35.12,-33.52,;31.17,-35.94,;29.86,-36.71,;31.17,-34.39,;29.86,-33.64,;28.53,-34.39,;27.18,-33.61,;25.85,-34.38,;24.51,-33.59,;23.19,-34.36,;23.19,-35.9,;21.84,-33.57,;29.86,-32.06,;31.2,-31.29,;28.53,-31.3,;28.53,-29.75,;29.87,-28.97,;29.87,-27.44,;27.21,-28.98,;25.88,-29.75,;27.21,-27.41,;25.88,-26.66,;24.57,-27.41,;23.21,-26.65,;23.23,-25.1,;21.9,-24.32,;20.56,-25.08,;20.55,-26.62,;21.89,-27.4,;25.88,-25.11,;27.23,-24.32,;24.57,-24.33,;24.57,-22.77,;25.92,-22,;25.92,-20.47,;23.24,-22.01,;21.91,-22.77,;23.24,-20.46,;21.91,-19.69,;20.59,-20.46,;19.25,-19.68,;19.25,-18.12,;17.92,-20.45,;21.91,-18.13,;23.27,-17.36,;20.59,-17.37,;20.59,-15.82,;21.95,-15.04,;21.95,-13.51,;23.29,-12.73,;23.29,-11.2,;24.64,-10.42,;19.26,-15.05,;17.95,-15.82,;19.26,-13.48,;17.95,-12.73,;16.62,-13.48,;15.27,-12.71,;15.27,-11.16,;13.96,-13.47,;17.95,-11.17,;19.29,-10.39,;16.62,-10.4,;16.62,-8.84,;15.3,-8.08,;13.97,-8.84,;15.3,-6.53,;13.97,-5.76,;12.66,-6.53,;11.31,-5.75,;9.98,-6.52,;11.31,-4.18,;13.97,-4.2,;15.33,-3.43,;12.66,-3.44,;12.66,-1.89,;14,-1.1,;15.36,-1.89,;14,.42,;11.33,-1.12,;10.01,-1.89,;11.33,.45,;10.01,1.21,;8.68,.45,;7.34,1.22,;10.01,2.76,;8.68,3.53,;11.35,3.54,)|
Structure
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