| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-secretase 1 |
|---|
| Ligand | BDBM50311847 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_619925 (CHEMBL1113136) |
|---|
| IC50 | 2400±n/a nM |
|---|
| Citation |  Yi Mok, N; Chadwick, J; Kellett, KA; Hooper, NM; Johnson, AP; Fishwick, CW Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening. Bioorg Med Chem Lett19:6770-4 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-secretase 1 |
|---|
| Name: | Beta-secretase 1 |
|---|
| Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 55755.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P56817 |
|---|
| Residue: | 501 |
|---|
| Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRQQHDDFADDISLLK
|
|
|
|---|
| BDBM50311847 |
|---|
| n/a |
|---|
| Name | BDBM50311847 |
|---|
| Synonyms: | 2-(3-(2-(2-hydroxy-5-nitrobenzoyl)hydrazono)-2-oxoindolin-1-yl)-N-p-tolylacetamide | CHEMBL1080295 | cid_5758016 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H19N5O6 |
|---|
| Mol. Mass. | 473.4376 |
|---|
| SMILES | Cc1ccc(NC(=O)CN2C(=O)C(=NNC(=O)c3cc(ccc3O)[N+]([O-])=O)c3ccccc23)cc1 |w:13.13| |
|---|
| Structure | 
|
|---|
Search and Browse
