| Reaction Details |
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 | Report a problem with these data |
| Target | Melatonin receptor type 1B |
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| Ligand | BDBM50316693 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_632479 (CHEMBL1108343) |
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| EC50 | >10000±n/a nM |
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| Citation |  Mésangeau, C; Pérès, B; Descamps-François, C; Chavatte, P; Audinot, V; Coumailleau, S; Boutin, JA; Delagrange, P; Bennejean, C; Renard, P; Caignard, DH; Berthelot, P; Yous, S Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands. Bioorg Med Chem18:3426-36 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melatonin receptor type 1B |
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| Name: | Melatonin receptor type 1B |
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| Synonyms: | MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 40203.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49286 |
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| Residue: | 362 |
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| Sequence: | MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLL
VILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVM
GLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS
LEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRL
CLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFN
SCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQAD
AL
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| BDBM50316693 |
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| n/a |
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| Name | BDBM50316693 |
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| Synonyms: | CHEMBL1095831 | N-[2-(7-{4-[8-(2-Acetylaminoethyl)-5,6,7,8-tetrahydronaphthalen-2-yloxy]butoxy}naphthalen-1-yl)ethyl]acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C32H40N2O4 |
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| Mol. Mass. | 516.671 |
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| SMILES | CC(=O)NCCC1CCCc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 |
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| Structure | 
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