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TargetMelatonin receptor
LigandBDBM50316693
Substrate/Competitorn/a
Meas. Tech.ChEMBL_632470
Ki 0.26±n/a nM
Citation Mésangeau CPérès BDescamps-François CChavatte PAudinot VCoumailleau SBoutin JADelagrange PBennejean CRenard PCaignard DHBerthelot PYous S Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands. Bioorg Med Chem 18:3426-36 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melatonin receptor
Name:Melatonin receptor
Synonyms:MTNR1A | MTNR1A protein | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A
Type:Enzyme
Mol. Mass.:39392.94
Organism:Homo sapiens (Human)
Description:P48039
Residue:350
Sequence:
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRN
AGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITG
IAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFA
QSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTM
FVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQ
NFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
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  Blast E-value cutoff:
BDBM50316693
n/a
NameBDBM50316693
Synonyms:CHEMBL1095831 | N-[2-(7-{4-[8-(2-Acetylaminoethyl)-5,6,7,8-tetrahydronaphthalen-2-yloxy]butoxy}naphthalen-1-yl)ethyl]acetamide
TypeSmall organic molecule
Emp. Form.C32H40N2O4
Mol. Mass.516.671
SMILESCC(=O)NCCC1CCCc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12
Structure
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