Ki Summary

Reaction Details

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Target

WD repeat-containing protein 5

Ligand

BDBM50318539

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_633068 (CHEMBL1118768)

160±n/a nM

Citation

Karatas, H; Townsend, EC; Bernard, D; Dou, Y; Wang, S Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction. J Med Chem53:5179-85 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

WD repeat-containing protein 5

Name:

WD repeat-containing protein 5

Synonyms:

Type:

Protein

Mol. Mass.:

36597.13

Organism:

Homo sapiens (Human)

Description:

P61964

Residue:

334

Sequence:

MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
TDVVISTACHPTENIIASAALENDKTIKLWKSDC

BDBM50318539

n/a

Name

BDBM50318539

Synonyms:

Ac-GSARAEVHLRKS-NH2 | CHEMBL1086448

Type

Small organic molecule

Emp. Form.

C56H98N22O17

Mol. Mass.

1351.5145

SMILES

CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)CNC(C)=O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O |r,wU:31.32,47.48,18.19,4.4,80.80,wD:52.55,8.15,36.44,69.69,22.28,89.89,(27.37,4.47,;27.37,2.95,;28.73,2.16,;26.02,2.16,;26.02,.64,;24.71,-.17,;23.37,.6,;23.37,2.12,;22.04,-.16,;22.04,-1.73,;23.37,-2.49,;24.77,-1.9,;25.79,-3.05,;25.01,-4.38,;23.51,-4.02,;20.72,.63,;19.39,-.15,;19.39,-1.72,;18.04,.63,;16.7,-.14,;15.35,.6,;15.35,2.12,;14.04,-.17,;14.04,-1.73,;15.35,-2.5,;15.35,-4.06,;14.01,-4.83,;16.68,-4.82,;12.71,.62,;11.39,-.17,;11.39,-1.74,;10.04,.6,;10.04,2.13,;8.7,-.16,;7.35,.59,;7.35,2.12,;6.03,-.17,;6.03,-1.73,;7.35,-2.5,;7.35,-4.07,;8.7,-4.81,;8.69,-6.35,;7.34,-7.14,;10,-7.07,;4.71,.63,;3.39,-.16,;3.39,-1.73,;2.04,.62,;2.04,2.14,;.68,-.11,;-.67,.62,;-.67,2.15,;-2,-.14,;-2,-1.7,;-.66,-2.46,;-3.29,.69,;-4.58,-.16,;-4.58,-1.7,;-5.93,.62,;-7.26,-.15,;-8.59,.62,;-9.92,-.15,;-8.59,2.16,;18.04,2.15,;19.39,2.94,;16.71,2.92,;27.37,-.15,;27.37,-1.71,;28.7,.63,;30.03,-.15,;30.03,-1.72,;31.35,-2.49,;31.35,-4.05,;32.69,-4.81,;32.66,-6.35,;31.32,-7.15,;34.02,-7.12,;31.35,.61,;31.35,2.14,;32.69,-.15,;34.03,.63,;34.03,2.15,;35.38,2.94,;35.38,4.46,;36.73,5.24,;36.75,6.77,;35.38,-.16,;35.38,-1.72,;36.71,.61,;38.05,-.16,;38.05,-1.72,;39.37,-2.48,;39.37,.6,;40.73,-.17,;39.37,2.13,)|

Structure