Ki Summary

Reaction Details

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Target

WD repeat-containing protein 5

Ligand

BDBM50318535

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_633068 (CHEMBL1118768)

7300±n/a nM

Citation

Karatas, H; Townsend, EC; Bernard, D; Dou, Y; Wang, S Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction. J Med Chem53:5179-85 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

WD repeat-containing protein 5

Name:

WD repeat-containing protein 5

Synonyms:

Type:

Protein

Mol. Mass.:

36597.13

Organism:

Homo sapiens (Human)

Description:

P61964

Residue:

334

Sequence:

MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
TDVVISTACHPTENIIASAALENDKTIKLWKSDC

BDBM50318535

n/a

Name

BDBM50318535

Synonyms:

CHEMBL1086456 | H2N-ARAEVHLRKS-NH2

Type

Small organic molecule

Emp. Form.

C49H88N20O13

Mol. Mass.

1165.3492

SMILES

CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(N)=O |r,wU:31.32,47.49,4.4,67.67,18.19,wD:22.28,56.56,36.44,76.76,8.15,(20.76,2.59,;20.76,1.08,;22.11,.3,;19.42,.3,;19.42,-1.22,;18.1,-2.03,;16.76,-1.27,;16.76,.25,;15.45,-2.03,;15.45,-3.58,;16.76,-4.34,;18.16,-3.75,;19.17,-4.89,;18.4,-6.21,;16.9,-5.87,;14.12,-1.26,;12.79,-2.02,;12.79,-3.58,;11.44,-1.25,;10.11,-2.02,;8.76,-1.28,;8.76,.24,;7.45,-2.04,;7.45,-3.6,;8.76,-4.36,;8.76,-5.91,;7.44,-6.63,;10.07,-6.66,;6.14,-1.22,;4.83,-2.02,;4.83,-3.58,;3.48,-1.25,;3.48,.27,;2.14,-2.01,;.77,-1.31,;.77,.21,;-.55,-2.06,;-.55,-3.61,;.77,-4.37,;.77,-5.93,;2.14,-6.63,;2.08,-8.17,;.76,-8.87,;3.41,-8.88,;-1.86,-1.27,;-3.19,-2.04,;-3.19,-3.57,;-4.53,-1.26,;-4.53,.28,;-5.85,-2.03,;11.44,.26,;12.79,1.04,;10.13,1.02,;20.76,-2,;20.76,-3.55,;22.09,-1.22,;23.43,-1.98,;23.43,-3.54,;24.74,-4.3,;24.74,-5.85,;26.07,-6.63,;26.06,-8.17,;24.71,-8.95,;27.36,-8.93,;24.74,-1.23,;24.74,.29,;26.07,-2,;27.4,-1.22,;27.4,.3,;28.74,1.08,;28.74,2.59,;30.09,3.37,;30.12,4.88,;28.74,-2,;28.74,-3.55,;30.08,-1.24,;31.42,-2.01,;31.42,-3.56,;32.73,-4.32,;32.73,-1.26,;34.07,-2.03,;32.73,.26,)|

Structure