| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-dependent protein kinase 2 |
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| Ligand | BDBM50319716 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_634834 (CHEMBL1120084) |
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| IC50 | 24±n/a nM |
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| Citation |  Bosanac, T; Hickey, ER; Ginn, J; Kashem, M; Kerr, S; Kugler, S; Li, X; Olague, A; Schlyer, S; Young, ER Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 3, aryl substituted pyrrolidines. Bioorg Med Chem Lett20:3746-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cGMP-dependent protein kinase 2 |
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| Name: | cGMP-dependent protein kinase 2 |
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| Synonyms: | CGK 2 | KGP2_HUMAN | PRKG2 | PRKGR2 | Type II cGMP-dependent protein kinase | cGKII |
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| Type: | PROTEIN |
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| Mol. Mass.: | 87448.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774533 |
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| Residue: | 762 |
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| Sequence: | MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK
QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG
AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM
VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC
TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID
CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL
ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS
MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA
MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS
ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK
IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN
LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK
ARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF
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| BDBM50319716 |
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| n/a |
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| Name | BDBM50319716 |
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| Synonyms: | (3S,4R)-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamide | CHEMBL1082821 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H17Cl2N3O2 |
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| Mol. Mass. | 402.274 |
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| SMILES | Clc1ccc(cc1)[C@@H]1CNC[C@H]1C(=O)Nc1cc2cc[nH]c(=O)c2cc1Cl |r| |
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| Structure | 
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