| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent noradrenaline transporter |
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| Ligand | BDBM50310656 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_634878 (CHEMBL1120510) |
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| Ki | 21±n/a nM |
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| Citation |  Fray, MJ; Fish, PV; Allan, GA; Bish, G; Clarke, N; Eccles, R; Harrison, AC; Le Net, JL; Phillips, SC; Regan, N; Sobry, C; Stobie, A; Wakenhut, F; Westbrook, D; Westbrook, SL; Whitlock, GA Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity. Bioorg Med Chem Lett20:3788-92 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent noradrenaline transporter |
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| Name: | Sodium-dependent noradrenaline transporter |
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| Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 69337.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23975 |
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| Residue: | 617 |
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| Sequence: | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
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| BDBM50310656 |
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| n/a |
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| Name | BDBM50310656 |
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| Synonyms: | (S)-2,3-dichloro-N-isobutyl-N-(pyrrolidin-3-yl)benzamide | CHEMBL1080787 | PF-18298 | PF-184298 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H20Cl2N2O |
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| Mol. Mass. | 315.238 |
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| SMILES | CC(C)CN([C@H]1CCNC1)C(=O)c1cccc(Cl)c1Cl |r| |
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| Structure | 
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