Reaction Details |
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Target | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
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Ligand | BDBM50321266 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_638412 (CHEMBL1167858) |
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IC50 | 128800±n/a nM |
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Citation | Argüelles, N; Sánchez-Sandoval, E; Mendieta, A; Villa-Tanaca, L; Garduño-Siciliano, L; Jiménez, F; Cruz, Mdel C; Medina-Franco, JL; Chamorro-Cevallos, G; Tamariz, J Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating alpha-asarone-based HMG-CoA reductase inhibitors. Bioorg Med Chem18:4238-48 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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3-hydroxy-3-methylglutaryl-coenzyme A reductase |
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Name: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
Synonyms: | HMDH_SCHPO | hmg1 | its12 |
Type: | PROTEIN |
Mol. Mass.: | 114890.37 |
Organism: | Schizosaccharomyces pombe |
Description: | ChEMBL_638412 |
Residue: | 1053 |
Sequence: | MIYKLAARYPIQVIAIVGILVSMAYFSFLEALTQEDFPVLIRALKRFGILDGFPNTRLPN
EMILKLSSVQGEDASVWEQIPAAELGGEGFVDFDITQWYYPANAKVDVAQLVEPYRNDCI
FHDASGACHFFFKEVGNWTVSSIALPSNLANPPIDYFLDSSSTVIQRILPAIREHGISWS
WLLQLIARTWMNTLKIASQASKTELLIVGTAYACMLISIVSLYLKMRRLGSKFWLFFSVL
LSTLFSVQFAMTLVRASGVRISLVSLIESLPFLINVVALDKAAELTRQVITRCSVSDSHS
PMHEDIAKACRNAAPPILRHFSFGIVVLAIFSYCNFGIKQFFLFAAVMIYDLLLLFSFFV
AILTLKLEMRRYNAKDDVRKVLIEEGLSESTARHVADGNDSSATTSAGSRYFKVRYGTKI
ILFIFIAFNLFELCSIPFKHYAATSAAAARLIPLVRSQYPDFKSQRLLDDGVFDDVLSAI
SSMSNIESPSVRLLPAVFYGAELSSTSFLSTIHSFINNWSHYISASFLSKWIVCALSLSI
AVNVFLLNAARLNSIKEEPEKKVVEKVVEVVKYIPSSNSSSIDDIQKDEIAQESVVRSLE
ECITLYNNGQISTLNDEEVVQLTLAKKIPLYALERVLKDVTRAVVIRRTVVSRSSRTKTL
ESSNCPVYHYDYSRVLNACCENVIGYMPLPLGVAGPLIIDGKPFYIPMATTEGALVASTM
RGCKAINAGGGAVTVLTRDQMSRGPCVAFPNLTRAGRAKIWLDSPEGQEVMKKAFNSTSR
FARLQHIKTALAGTRLFIRFCTSTGDAMGMNMISKGVEHALVVMSNDAGFDDMQVISVSG
NYCTDKKPAAINWIDGRGKSVIAEAIIPGDAVKSVLKTTVEDLVKLNVDKNLIGSAMAGS
VGGFNAHAANIVTAVYLATGQDPAQNVESSNCITLMDNVDGNLQLSVSMPSIEVGTIGGG
TVLEPQGAMLDLLGVRGAHMTSPGDNSRQLARVVAAAVMAGELSLCSALASGHLVKSHIG
LNRSALNTPAMDSSAKKPATDALKSVNSRVPGR
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BDBM50321266 |
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n/a |
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Name | BDBM50321266 |
Synonyms: | 4-chloro-N-(2-(2-methoxy-4-(prop-1-enyl)phenoxy)ethyl)benzamide | CHEMBL1163690 |
Type | Small organic molecule |
Emp. Form. | C19H20ClNO3 |
Mol. Mass. | 345.82 |
SMILES | COc1cc(\C=C\C)ccc1OCCNC(=O)c1ccc(Cl)cc1 |
Structure |
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