| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase I, thermostable |
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| Ligand | BDBM50321616 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_639807 (CHEMBL1175752) |
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| IC50 | 6400±n/a nM |
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| Citation |  Liu, XH; Liu, HF; Shen, X; Song, BA; Bhadury, PS; Zhu, HL; Liu, JX; Qi, XB Synthesis and molecular docking studies of novel 2-chloro-pyridine derivatives containing flavone moieties as potential antitumor agents. Bioorg Med Chem Lett20:4163-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase I, thermostable |
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| Name: | DNA polymerase I, thermostable |
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| Synonyms: | DNA polymerase I, thermostable | DPO1_THEAQ | Taq polymerase 1 | pol1 | polA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 93906.95 |
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| Organism: | Thermus aquaticus |
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| Description: | ChEMBL_1289218 |
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| Residue: | 832 |
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| Sequence: | MRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYGFAKSLLKALKEDGD
AVIVVFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADD
VLASLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWA
DYRALTGDESDNLPGVKGIGEKTARKLLEEWGSLEALLKNLDRLKPAIREKILAHMDDLK
LSWDLAKVRTDLPLEVDFAKRREPDRERLRAFLERLEFGSLLHEFGLLESPKALEEAPWP
PPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAKDLSVLA
LREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRL
EGEERLLWLYREVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGH
PFNLNSRDQLERVLFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTK
LKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRRAFIA
EEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRR
AAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYV
ETLFGRRRYVPDLEARVKSVREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARML
LQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
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| BDBM50321616 |
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| n/a |
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| Name | BDBM50321616 |
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| Synonyms: | 7-((6-chloropyridin-3-yl)methoxy)-2-(4-methoxyphenyl)-4H-chromen-4-one | CHEMBL1170702 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H16ClNO4 |
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| Mol. Mass. | 393.82 |
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| SMILES | COc1ccc(cc1)-c1cc(=O)c2ccc(OCc3ccc(Cl)nc3)cc2o1 |
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| Structure | 
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