| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine aminopeptidase 1 |
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| Ligand | BDBM50180733 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_639876 (CHEMBL1173891) |
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| IC50 | 32600±n/a nM |
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| Citation |  Altmeyer, MA; Marschner, A; Schiffmann, R; Klein, CD Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors. Bioorg Med Chem Lett20:4038-44 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Methionine aminopeptidase 1 |
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| Name: | Methionine aminopeptidase 1 |
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| Synonyms: | Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 43220.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells. |
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| Residue: | 386 |
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| Sequence: | MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
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| BDBM50180733 |
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| n/a |
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| Name | BDBM50180733 |
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| Synonyms: | 5-Methyl-2-pyridin-2-yl-1H-benzoimidazole | 5-methyl-2-(pyridin-2-yl)-1H-benzo[d]imidazole | 5-methyl-2-pyridin-2-yl-1(3)H-benzoimidazole | CHEMBL352049 | US8748618, LD-2-11 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H11N3 |
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| Mol. Mass. | 209.2465 |
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| SMILES | Cc1ccc2nc([nH]c2c1)-c1ccccn1 |
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| Structure | 
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