| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteinyl leukotriene receptor 1 |
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| Ligand | BDBM50064076 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_647615 (CHEMBL1219966) |
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| IC50 | 382±n/a nM |
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| Citation |  Dong, X; Wang, L; Huang, X; Liu, T; Wei, E; Du, L; Yang, B; Hu, Y Pharmacophore identification, synthesis, and biological evaluation of carboxylated chalcone derivatives as CysLT1 antagonists. Bioorg Med Chem18:5519-27 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteinyl leukotriene receptor 1 |
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| Name: | Cysteinyl leukotriene receptor 1 |
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| Synonyms: | CLTR1_HUMAN | CYSLT1 | CYSLTR1 | Cysteinyl leukotriene D4 receptor | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 1 | HG55 | HMTMF81 | LTD4 receptor | Leukotriene Cysteinyl 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38565.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271 |
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| Residue: | 337 |
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| Sequence: | MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQV
YMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFF
RCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDN
QTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTA
AFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGG
NFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
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| BDBM50064076 |
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| n/a |
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| Name | BDBM50064076 |
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| Synonyms: | 6-bromo-4-oxo-N-(phenylsulfonyl)-2-(4-(quinolin-2-ylmethoxy)phenyl)-4H-chromene-8-carboxamide | CHEMBL285994 | N-{6-Bromo-4-oxo-2-[4-(quinolin-2-ylmethoxy)-phenyl]-4H-chromene-8-carbonyl}-benzenesulfonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C32H21BrN2O6S |
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| Mol. Mass. | 641.488 |
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| SMILES | Brc1cc(C(=O)NS(=O)(=O)c2ccccc2)c2oc(cc(=O)c2c1)-c1ccc(OCc2ccc3ccccc3n2)cc1 |
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| Structure | 
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