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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase ABL1 | ||
| Ligand | BDBM50378808 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_652025 (CHEMBL1227835) | ||
| Ki | 70±n/a nM | ||
| Citation |  Kraus, GA; Gupta, V; Mokhtarian, M; Mehanovic, S; Nilsen-Hamilton, M New effective inhibitors of the Abelson kinase. Bioorg Med Chem18:6316-21 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase ABL1 | |||
| Name: | Tyrosine-protein kinase ABL1 | ||
| Synonyms: | ABL | ABL1 | ABL1_HUMAN | Abelson murine leukemia viral oncogene homolog 1 | JTK7 | Proto-oncogene c-Abl | Proto-oncogene tyrosine-protein kinase ABL1 | Tyrosine-protein kinase (ABL) | Tyrosine-protein kinase ABL | Tyrosine-protein kinase ABL1 (ABL) | V-abl Abelson murine leukemia viral oncogene homolog 1 | c-ABL | p150 | tyrosine-protein kinase ABL1 isoform a | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 122897.30 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P00519 | ||
| Residue: | 1130 | ||
| Sequence: |
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| BDBM50378808 | |||
| n/a | |||
| Name | BDBM50378808 | ||
| Synonyms: | CHEMBL1223413 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H18Cl2N4OS | ||
| Mol. Mass. | 457.376 | ||
| SMILES | CSc1cccc(CNc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 |(-11.39,-21.23,;-10.05,-20.46,;-8.72,-21.23,;-8.72,-22.77,;-7.39,-23.54,;-6.05,-22.77,;-6.05,-21.22,;-4.72,-20.45,;-3.39,-21.21,;-2.06,-20.44,;-2.07,-18.91,;-.75,-18.13,;.6,-18.89,;1.93,-18.12,;3.26,-18.9,;4.59,-18.13,;4.59,-16.6,;3.26,-15.83,;5.92,-15.83,;7.26,-16.6,;7.26,-18.14,;5.93,-18.91,;5.92,-20.45,;3.26,-20.44,;4.59,-21.21,;1.93,-21.2,;1.92,-22.74,;.6,-20.44,;-.73,-21.21,;-7.39,-20.46,)| | ||
| Structure | 
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