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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase ABL1 | ||
| Ligand | BDBM50378810 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_652025 (CHEMBL1227835) | ||
| Ki | 20±n/a nM | ||
| Citation |  Kraus, GA; Gupta, V; Mokhtarian, M; Mehanovic, S; Nilsen-Hamilton, M New effective inhibitors of the Abelson kinase. Bioorg Med Chem18:6316-21 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase ABL1 | |||
| Name: | Tyrosine-protein kinase ABL1 | ||
| Synonyms: | ABL | ABL1 | ABL1_HUMAN | Abelson murine leukemia viral oncogene homolog 1 | JTK7 | Proto-oncogene c-Abl | Proto-oncogene tyrosine-protein kinase ABL1 | Tyrosine-protein kinase (ABL) | Tyrosine-protein kinase ABL | Tyrosine-protein kinase ABL1 (ABL) | V-abl Abelson murine leukemia viral oncogene homolog 1 | c-ABL | p150 | tyrosine-protein kinase ABL1 isoform a | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 122897.30 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P00519 | ||
| Residue: | 1130 | ||
| Sequence: |
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| BDBM50378810 | |||
| n/a | |||
| Name | BDBM50378810 | ||
| Synonyms: | CHEMBL1223482 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H20Cl2N6O2 | ||
| Mol. Mass. | 483.35 | ||
| SMILES | Cn1c2nc(NCc3cccc(NC(=O)CN)c3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(51.48,-23.91,;51.49,-22.37,;50.16,-21.61,;48.83,-22.38,;47.5,-21.61,;46.17,-22.38,;44.83,-21.62,;43.5,-22.39,;43.51,-23.94,;42.17,-24.72,;40.84,-23.94,;40.84,-22.4,;39.5,-21.63,;38.17,-22.4,;38.17,-23.94,;36.84,-21.63,;36.84,-20.09,;42.17,-21.63,;47.49,-20.08,;48.81,-19.3,;50.16,-20.06,;51.49,-19.29,;52.82,-20.07,;54.16,-19.3,;54.16,-17.77,;52.82,-17,;55.48,-17,;56.83,-17.77,;56.82,-19.31,;55.49,-20.08,;55.49,-21.62,;52.82,-21.61,;54.16,-22.38,)| | ||
| Structure | 
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