| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4 |
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| Ligand | BDBM7238 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_660568 (CHEMBL1250276) |
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| IC50 | 300±n/a nM |
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| Citation |  Sridhar, J; Akula, N; Pattabiraman, N Selectivity and potency of cyclin-dependent kinase inhibitors. AAPS J8:204-21 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Cyclin-dependent kinase 4 |
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| Name: | Cyclin-dependent kinase 4 |
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| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33731.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11802 |
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| Residue: | 303 |
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| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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| BDBM7238 |
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| n/a |
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| Name | BDBM7238 |
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| Synonyms: | (3Z)-3-(1H-imidazol-5-ylmethylidene)-5-methoxy-2,3-dihydro-1H-indol-2-one | 3-(3H-Imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one | SU9516 | cid_5289419 | imidazole indolinone driv. |
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| Type | Small organic molecule |
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| Emp. Form. | C13H11N3O2 |
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| Mol. Mass. | 241.2453 |
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| SMILES | COc1ccc2NC(=O)C(=Cc3cnc[nH]3)c2c1 |w:10.10| |
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| Structure | 
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