Ki Summary

Reaction Details

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Target

Peptidyl-prolyl cis-trans isomerase A

Ligand

BDBM50330186

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_676203 (CHEMBL1273323)

IC50

23±n/a nM

Citation

Scribner, A; Houck, D; Huang, Z; Mosier, S; Peel, M; Scorneaux, B Synthesis and biological evaluation of [D-lysine]8cyclosporin A analogs as potential anti-HCV agents. Bioorg Med Chem Lett20:6542-6 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Peptidyl-prolyl cis-trans isomerase A

Name:

Peptidyl-prolyl cis-trans isomerase A

Synonyms:

Type:

Protein

Mol. Mass.:

18015.32

Organism:

Homo sapiens (Human)

Description:

P62937

Residue:

165

Sequence:

MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGF
MCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTE
WLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE

BDBM50330186

n/a

Name

BDBM50330186

Synonyms:

3-((2R,5S,8S,11S,14S,17S,23S,26S,29S,32S)-17-ethyl-14-((1R,2R)-1-hydroxy-2-methylhex-4-enyl)-5,8,23,29-tetraisobutyl-11,26-diisopropyl-4,7,10,13,19,22,28,32-octamethyl-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl)propanenitrile | CHEMBL1269584

Type

Small organic molecule

Emp. Form.

C64H112N12O12

Mol. Mass.

1241.6473

SMILES

CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](CCC#N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C |r|

Structure