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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium- and chloride-dependent glycine transporter 1 | ||
| Ligand | BDBM50335008 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_702705 (CHEMBL1657779) | ||
| IC50 | 83±n/a nM | ||
| Citation |  Kohara, A; Doihara, H; Saita, K; Aota, M Synthesis and biological evaluation of 3-biphenyl-4-yl-4-phenyl-4H-1,2,4-triazoles as novel glycine transporter 1 inhibitors. J Med Chem54:387-91 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium- and chloride-dependent glycine transporter 1 | |||
| Name: | Sodium- and chloride-dependent glycine transporter 1 | ||
| Synonyms: | GlyT-1 | GlyT1 | Glycine transporter 1 | SC6A9_RAT | Slc6a9 | Sodium- and chloride-dependent glycine transporter 1 | Solute carrier family 6 member 9 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 71066.17 | ||
| Organism: | attus norvegicus (Rat) | ||
| Description: | Glycine-1-transporter 0 HUMAN::P28572 | ||
| Residue: | 638 | ||
| Sequence: |
| ||
| BDBM50335008 | |||
| n/a | |||
| Name | BDBM50335008 | ||
| Synonyms: | 5-Biphenyl-4-yl-4-(2-fluorophenyl)-N-methyl-4H-1,2,4-triazol-3-amine | CHEMBL1649969 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H17FN4 | ||
| Mol. Mass. | 344.3849 | ||
| SMILES | CNc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F |(17.26,-39.7,;16.11,-40.73,;14.65,-40.25,;14.17,-38.79,;12.63,-38.79,;12.16,-40.25,;10.83,-41.03,;10.84,-42.57,;9.51,-43.34,;8.17,-42.57,;8.16,-41.04,;9.49,-40.26,;6.85,-43.35,;5.51,-42.58,;4.18,-43.35,;4.18,-44.9,;5.51,-45.67,;6.85,-44.9,;13.4,-41.16,;13.4,-42.69,;12.06,-43.45,;12.06,-44.99,;13.39,-45.77,;14.73,-44.99,;14.73,-43.45,;16.06,-42.68,)| | ||
| Structure | 
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