| Reaction Details |
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 | Report a problem with these data |
| Target | Fructose-1,6-bisphosphatase 1 |
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| Ligand | BDBM50335036 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_702737 (CHEMBL1657811) |
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| IC50 | 12±n/a nM |
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| Citation |  Fan, Y; Jiang, T; Cashion, DK; Sun, Z; Tian, F; DaRe, J; Lemus, R Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase. J Med Chem54:153-65 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Fructose-1,6-bisphosphatase 1 |
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| Name: | Fructose-1,6-bisphosphatase 1 |
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| Synonyms: | D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase) |
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| Type: | Protein |
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| Mol. Mass.: | 36843.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Liver FBPase (P09467) |
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| Residue: | 338 |
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| Sequence: | MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGI
AGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDP
LDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDC
GVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK
EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
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| BDBM50335036 |
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| n/a |
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| Name | BDBM50335036 |
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| Synonyms: | 2-Amino-5-cyclobutyl-4-[2-(5-phosphono)furanyl]thiazole | CHEMBL1650181 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H17N2O4PS |
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| Mol. Mass. | 316.313 |
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| SMILES | CC(C)(C)Cc1sc(N)nc1-c1ccc(o1)P(O)(O)=O |
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| Structure | 
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