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TargetFructose-1,6-bisphosphatase 1
LigandBDBM50335057
Substrate/Competitorn/a
Meas. Tech.ChEMBL_702737 (CHEMBL1657811)
IC50 14±n/a nM
Citation Fan, YJiang, TCashion, DKSun, ZTian, FDaRe, JLemus, R Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase. J Med Chem54:153-65 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Fructose-1,6-bisphosphatase 1
Name:Fructose-1,6-bisphosphatase 1
Synonyms:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:Protein
Mol. Mass.:36843.58
Organism:Homo sapiens (Human)
Description:Liver FBPase (P09467)
Residue:338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGI
AGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDP
LDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDC
GVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK
EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
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  Blast E-value cutoff:
BDBM50335057
n/a
NameBDBM50335057
Synonyms:5-(2-amino-5-phenylthiazol-4-yl)furan-2-ylphosphonic acid | CHEMBL504104
TypeSmall organic molecule
Emp. Form.C13H11N2O4PS
Mol. Mass.322.276
SMILESNc1nc(-c2ccc(o2)P(O)(O)=O)c(s1)-c1ccccc1
Structure
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