| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase 3 |
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| Ligand | BDBM50335188 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_701551 (CHEMBL1656190) |
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| IC50 | >100±n/a nM |
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| Citation |  Kerekes, AD; Esposite, SJ; Tagat, JR; Xiao, Y; Terracina, GA Aurora kinase inhibitors based on the imidazo[1,2-a]pyrazine core: fluorine and deuterium incorporation improve oral absorption and exposure. J Med Chem54:201-10 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase 3 |
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| Name: | Serine/threonine-protein kinase 3 |
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| Synonyms: | KRS1 | MST-2 | MST2 | Mammalian STE20-like protein kinase 2 | STE20-Like Kinase MST2 | STK3 | STK3_HUMAN | Serine/threonine-protein kinase 3 | Serine/threonine-protein kinase 3 (MST2) | Serine/threonine-protein kinase 3/4 | Serine/threonine-protein kinase Krs-1 | Serine/threonine-protein kinase MST2 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 56284.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 491 |
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| Sequence: | MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV
ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIE
DEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT
VIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPT
FRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAK
RHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLES
DLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPM
SKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDA
MDAKKRRQQNF
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| BDBM50335188 |
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| n/a |
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| Name | BDBM50335188 |
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| Synonyms: | CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluoro-1-pyrrolidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18F2N8S |
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| Mol. Mass. | 416.451 |
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| SMILES | Cc1cn2c(cnc2c(Nc2cc(CN3CCC(F)(F)C3)ns2)n1)-c1cn[nH]c1 |
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| Structure | 
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