| Reaction Details |
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 | Report a problem with these data |
| Target | Fibroblast growth factor receptor 3 |
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| Ligand | BDBM50338873 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_727269 (CHEMBL1687363) |
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| IC50 | 21.5±n/a nM |
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| Citation |  Kim, MH; Kim, M; Yu, H; Kim, H; Yoo, KH; Sim, T; Hah, JM Structure based design and syntheses of amino-1H-pyrazole amide derivatives as selective Raf kinase inhibitors in melanoma cells. Bioorg Med Chem19:1915-23 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Fibroblast growth factor receptor 3 |
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| Name: | Fibroblast growth factor receptor 3 |
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| Synonyms: | CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4 |
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| Type: | Protein |
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| Mol. Mass.: | 87699.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22607 |
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| Residue: | 806 |
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| Sequence: | MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELS
CPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCH
FSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAG
NPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQT
YTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGP
DGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAE
EELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLK
RQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGE
GCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIIN
LLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQ
VARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKW
MAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCT
HDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSS
SSSGDDSVFAHDLLPPAPPSSGGSRT
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| BDBM50338873 |
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| n/a |
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| Name | BDBM50338873 |
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| Synonyms: | CHEMBL1684800 | N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-2-methylbenzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C27H24ClF3N6O3 |
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| Mol. Mass. | 572.966 |
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| SMILES | COc1ccc(Cn2ncc(NC(=O)c3cc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)ccc3C)c2N)cc1 |
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| Structure | 
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