| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-dependent protein kinase catalytic subunit beta |
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| Ligand | BDBM50342212 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_743045 (CHEMBL1768516) |
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| IC50 | 23550±n/a nM |
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| Citation |  Djung, JF; Mears, RJ; Montalbetti, CA; Coulter, TS; Golebiowski, A; Carr, AN; Barker, O; Greis, KD; Zhou, S; Dolan, E; Davis, GF The synthesis and evaluation of indolylureas as PKCa inhibitors. Bioorg Med Chem19:2742-50 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-dependent protein kinase catalytic subunit beta |
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| Name: | cAMP-dependent protein kinase catalytic subunit beta |
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| Synonyms: | KAPCB_HUMAN | PKA C-beta | PKAC-beta | PRKACB | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase beta-1 catalytic subunit | cAMP-dependent protein kinase catalytic subunit beta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40631.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_586348 |
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| Residue: | 351 |
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| Sequence: | MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML
VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFAT
TDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF
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| BDBM50342212 |
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| n/a |
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| Name | BDBM50342212 |
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| Synonyms: | 1-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(4-phenylpyrimidin-2-yl)urea | CHEMBL1766422 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N6O |
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| Mol. Mass. | 414.5028 |
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| SMILES | CN(C)CCCn1cc(NC(=O)Nc2nccc(n2)-c2ccccc2)c2ccccc12 |
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| Structure | 
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