Reaction Details |
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Target | Serine hydroxymethyltransferase, cytosolic |
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Ligand | BDBM18796 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_745717 (CHEMBL1776087) |
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Ki | 19100±n/a nM |
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Citation | Daidone, F; Florio, R; Rinaldo, S; Contestabile, R; di Salvo, ML; Cutruzzolà, F; Bossa, F; Paiardini, A In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed. Eur J Med Chem46:1616-21 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine hydroxymethyltransferase, cytosolic |
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Name: | Serine hydroxymethyltransferase, cytosolic |
Synonyms: | GLYC_HUMAN | Glycine hydroxymethyltransferase | SHMT | SHMT1 | Serine methylase |
Type: | PROTEIN |
Mol. Mass.: | 53091.10 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_745716 |
Residue: | 483 |
Sequence: | MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA
VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG
SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY
INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV
VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGL
QGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL
VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK
VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL
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BDBM18796 |
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n/a |
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Name | BDBM18796 |
Synonyms: | (2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioic acid | LY231514 | Pemetrexed |
Type | Small organic molecule |
Emp. Form. | C20H21N5O6 |
Mol. Mass. | 427.4106 |
SMILES | Nc1nc2[nH]cc(CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)c2c(=O)[nH]1 |r| |
Structure |
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