| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine hydroxymethyltransferase, cytosolic |
|---|
| Ligand | BDBM18796 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_745719 (CHEMBL1776089) |
|---|
| Ki | 33000±n/a nM |
|---|
| Citation |  Daidone, F; Florio, R; Rinaldo, S; Contestabile, R; di Salvo, ML; Cutruzzolà, F; Bossa, F; Paiardini, A In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed. Eur J Med Chem46:1616-21 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine hydroxymethyltransferase, cytosolic |
|---|
| Name: | Serine hydroxymethyltransferase, cytosolic |
|---|
| Synonyms: | GLYC_HUMAN | Glycine hydroxymethyltransferase | SHMT | SHMT1 | Serine methylase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 53091.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_745716 |
|---|
| Residue: | 483 |
|---|
| Sequence: | MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA
VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG
SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY
INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV
VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGL
QGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL
VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK
VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL
PDF
|
|
|
|---|
| BDBM18796 |
|---|
| n/a |
|---|
| Name | BDBM18796 |
|---|
| Synonyms: | (2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioic acid | LY231514 | Pemetrexed |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H21N5O6 |
|---|
| Mol. Mass. | 427.4106 |
|---|
| SMILES | Nc1nc2[nH]cc(CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)c2c(=O)[nH]1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
