Reaction Details |
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Target | TGF-beta receptor type-1 |
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Ligand | BDBM50355209 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_772820 (CHEMBL1837692) |
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IC50 | 2.37±n/a nM |
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Citation | Jin, CH; Krishnaiah, M; Sreenu, D; Subrahmanyam, VB; Rao, KS; Mohan, AV; Park, CY; Son, JY; Sheen, YY; Kim, DK Synthesis and biological evaluation of 1-substituted-3-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazoles as transforming growth factor-ß type 1 receptor kinase inhibitors. Bioorg Med Chem Lett21:6049-53 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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TGF-beta receptor type-1 |
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Name: | TGF-beta receptor type-1 |
Synonyms: | ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I |
Type: | enzyme |
Mol. Mass.: | 55968.24 |
Organism: | Homo sapiens (Human) |
Description: | P36897 |
Residue: | 503 |
Sequence: | MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
ARLTALRIKKTLSQLSQQEGIKM
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BDBM50355209 |
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n/a |
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Name | BDBM50355209 |
Synonyms: | CHEMBL1835519 |
Type | Small organic molecule |
Emp. Form. | C22H16ClN7S |
Mol. Mass. | 445.927 |
SMILES | Cc1cccc(n1)-c1nn(cc1-c1ccc2ncnn2c1)C(=S)Nc1cccc(Cl)c1 |
Structure |
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