| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk1 |
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| Ligand | BDBM50379749 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_812462 (CHEMBL2014248) |
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| IC50 | 113±n/a nM |
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| Citation |  Dudkin, VY; Rickert, K; Kreatsoulas, C; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Yan, Y; Ikuta, M; Stirdivant, SM; Drakas, RA; Walsh, ES; Hamilton, K; Buser, CA; Lobell, RB; Sepp-Lorenzino, L Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates. Bioorg Med Chem Lett22:2609-12 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Chk1 |
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| Name: | Serine/threonine-protein kinase Chk1 |
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| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 54443.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_166295192 |
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| Residue: | 476 |
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| Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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| BDBM50379749 |
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| n/a |
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| Name | BDBM50379749 |
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| Synonyms: | CHEMBL2011332 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22N6O2S2 |
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| Mol. Mass. | 430.547 |
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| SMILES | Cc1ccc(cn1)-c1cnc(Nc2cc(ccn2)N2CCN(CC2)S(C)(=O)=O)s1 |
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| Structure | 
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