| Reaction Details |
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 | Report a problem with these data |
| Target | Oxysterols receptor LXR-beta |
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| Ligand | BDBM50380067 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_810759 (CHEMBL2015992) |
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| IC50 | 900±n/a nM |
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| Citation |  Kopecky, DJ; Jiao, XY; Fisher, B; McKendry, S; Labelle, M; Piper, DE; Coward, P; Shiau, AK; Escaron, P; Danao, J; Chai, A; Jaen, J; Kayser, F Discovery of a new binding mode for a series of liver X receptor agonists. Bioorg Med Chem Lett22:2407-10 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Oxysterols receptor LXR-beta |
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| Name: | Oxysterols receptor LXR-beta |
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| Synonyms: | LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 50978.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P55055 |
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| Residue: | 460 |
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| Sequence: | MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR
SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI
ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR
RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
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| BDBM50380067 |
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| n/a |
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| Name | BDBM50380067 |
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| Synonyms: | CHEMBL2012765 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25F3N2O4S |
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| Mol. Mass. | 482.516 |
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| SMILES | COCCn1cccc1C(OC)(c1ccc(cc1)N(C)S(=O)(=O)c1ccccc1)C(F)(F)F |
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| Structure | 
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