| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50380093 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_810973 (CHEMBL2016367) |
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| IC50 | >250000±n/a nM |
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| Citation |  Karoli, T; Mamidyala, SK; Zuegg, J; Fry, SR; Tee, EH; Bradford, TA; Madala, PK; Huang, JX; Ramu, S; Butler, MS; Cooper, MA Structure aided design of chimeric antibiotics. Bioorg Med Chem Lett22:2428-33 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50380093 |
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| n/a |
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| Name | BDBM50380093 |
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| Synonyms: | CHEMBL2012917 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19FN4O3 |
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| Mol. Mass. | 370.3776 |
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| SMILES | OC(=O)c1cn(C2CC2)c2nc(N3CCN(CC#C)CC3)c(F)cc2c1=O |
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| Structure | 
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