Ki Summary

Reaction Details

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Target

Cholecystokinin receptor type A

Ligand

BDBM50380728

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_813439 (CHEMBL2019335)

IC50

14.7±n/a nM

Citation

Cameron, KO; Beretta, EE; Chen, Y; Chu-Moyer, M; Fernando, D; Gao, H; Kohrt, J; Lavergne, S; Jardine, Pda S; Guzman-Perez, A; Hoth, C; Perry, DA; Hadcock, JR; Gautreau, D; Makowski, M; Perez, S; Polivkova, J; Rogers, L; Scott, DO; Swick, AG; Thiede, L; Trebino, CE; Trilles, RV; Wilmowski, J; Zhang, Y Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists. Bioorg Med Chem Lett22:2943-7 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cholecystokinin receptor type A

Name:

Cholecystokinin receptor type A

Synonyms:

CCKAR_RAT | Cckar | Cholecystokinin peripheral | Cholecystokinin receptor | Cholecystokinin receptor type A

Type:

Enzyme Catalytic Domain

Mol. Mass.:

49676.37

Organism:

RAT

Description:

Cholecystokinin central 0 RAT::P30551

Residue:

444

Sequence:

MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQI
LLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLK
DFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAAT
WCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVM
VVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQL
SSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAE
KHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEE
DGRTIRALLSRYSYSHMSTSAPPP

BDBM50380728

n/a

Name

BDBM50380728

Synonyms:

CHEMBL2017835

Type

Small organic molecule

Emp. Form.

C40H39N7O2

Mol. Mass.

649.7834

SMILES

Cc1cc(C)cc(C[C@H]2CCCCN2C(=O)CN2c3ccccc3-n3c(nnc3-c3ccccc3)[C@H](Cc3n[nH]c4ccccc34)C2=O)c1 |r|

Structure