Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase receptor TYRO3

Ligand

BDBM50380766

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_813619 (CHEMBL2019768)

IC50

20±n/a nM

Citation

Forns, P; Esteve, C; Taboada, L; Alonso, JA; Orellana, A; Maldonado, M; Carreño, C; Ramis, I; López, M; Miralpeix, M; Vidal, B Pyrazine-based Syk kinase inhibitors. Bioorg Med Chem Lett22:2784-8 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase receptor TYRO3

Name:

Tyrosine-protein kinase receptor TYRO3

Synonyms:

BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY

Type:

Protein

Mol. Mass.:

96894.13

Organism:

Homo sapiens (Human)

Description:

Q06418

Residue:

890

Sequence:

MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPV
KLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVE
DGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKI
GGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSN
ASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRC
ANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKL
SWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQ
GPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAA
RSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQE
DGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPM
VILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARN
CMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGV
TMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFT
CLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAV
GGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC

BDBM50380766

n/a

Name

BDBM50380766

Synonyms:

CHEMBL2018146

Type

Small organic molecule

Emp. Form.

C26H30N6O2

Mol. Mass.

458.5554

SMILES

CCn1cc(cn1)-c1cccc(c1)-c1cnc(N)c(n1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:30.34,wD:23.25,TLB:31:30:23:27.25.26,22:23:29:27.26.32,THB:25:24:29:27.26.32,25:26:23.24.33:29,32:26:23:33.30.29,32:30:23:27.25.26,(-9.62,-2.09,;-8.88,-3.44,;-7.34,-3.48,;-6.41,-2.25,;-4.95,-2.76,;-4.99,-4.3,;-6.47,-4.74,;-3.68,-1.88,;-3.66,-.34,;-2.32,.41,;-1,-.37,;-1.01,-1.92,;-2.36,-2.67,;.3,-2.7,;.28,-4.25,;1.6,-5.03,;2.95,-4.28,;4.27,-5.06,;2.96,-2.73,;1.64,-1.95,;4.3,-1.97,;5.63,-2.76,;4.32,-.43,;5.64,.33,;7.15,.72,;8.54,.13,;9.58,1.39,;8.18,1.07,;6.86,1.58,;6.88,3.07,;8.23,3.52,;8.29,5.06,;9.62,2.92,;7.17,2.3,)|

Structure