| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase TXK |
|---|
| Ligand | BDBM50381092 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_814176 (CHEMBL2020890) |
|---|
| IC50 | 73.8±n/a nM |
|---|
| Citation |  McLean, LR; Zhang, Y; Zaidi, N; Bi, X; Wang, R; Dharanipragada, R; Jurcak, JG; Gillespy, TA; Zhao, Z; Musick, KY; Choi, YM; Barrague, M; Peppard, J; Smicker, M; Duguid, M; Parkar, A; Fordham, J; Kominos, D X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase. Bioorg Med Chem Lett22:3296-300 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase TXK |
|---|
| Name: | Tyrosine-protein kinase TXK |
|---|
| Synonyms: | PTK4 | Protein-tyrosine kinase 4 | RLK | Resting lymphocyte kinase | TXK | TXK_HUMAN | Tyrosine-protein kinase TXK (TXK) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 61268.80 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P42681 |
|---|
| Residue: | 527 |
|---|
| Sequence: | MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSN
TGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWW
KARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRH
LGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMT
RLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKA
INEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG
KLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEY
VSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAIS
EGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW
|
|
|
|---|
| BDBM50381092 |
|---|
| n/a |
|---|
| Name | BDBM50381092 |
|---|
| Synonyms: | CHEMBL2017552 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H15N3OS |
|---|
| Mol. Mass. | 297.375 |
|---|
| SMILES | CC(C)(O)c1ccc2cc([nH]c2c1)-c1n[nH]c2ccsc12 |
|---|
| Structure | 
|
|---|
Search and Browse
