| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PknB |
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| Ligand | BDBM50381129 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_814187 (CHEMBL2020901) |
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| IC50 | 55±n/a nM |
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| Citation |  Chapman, TM; Bouloc, N; Buxton, RS; Chugh, J; Lougheed, KE; Osborne, SA; Saxty, B; Smerdon, SJ; Taylor, DL; Whalley, D Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis. Bioorg Med Chem Lett22:3349-53 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PknB |
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| Name: | Serine/threonine-protein kinase PknB |
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| Synonyms: | PKNB_MYCTU | pknB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66497.93 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | ChEMBL_774233 |
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| Residue: | 626 |
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| Sequence: | MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRREA
QNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIA
DACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTA
QYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARH
EGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEPPEAPKVLTDAERTSLLSSA
AGNLSGPRTDPLPRQDLDDTDRDRSIGSVGRWVAVVAVLAVLTVVVTIAINTFGGITRDV
QVPDVRGQSSADAIATLQNRGFKIRTLQKPDSTIPPDHVIGTDPAANTSVSAGDEITVNV
STGPEQREIPDVSTLTYAEAVKKLTAAGFGRFKQANSPSTPELVGKVIGTNPPANQTSAI
TNVVIIIVGSGPATKDIPDVAGQTVDVAQKNLNVYGFTKFSQASVDSPRPAGEVTGTNPP
AGTTVPVDSVIELQVSKGNQFVMPDLSGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQH
NRVVYQNPPAGTGVNRDGIITLRFGQ
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| BDBM50381129 |
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| n/a |
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| Name | BDBM50381129 |
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| Synonyms: | CHEMBL2017730 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H29N7 |
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| Mol. Mass. | 403.5233 |
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| SMILES | CN1CCC(CNc2cc(Nc3cc(n[nH]3)C3CC3)nc(n2)-c2ccccc2)CC1 |
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| Structure | 
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