Reaction Details |
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Target | Serine/threonine-protein kinase PknB |
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Ligand | BDBM50381133 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_814187 (CHEMBL2020901) |
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IC50 | 56±n/a nM |
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Citation | Chapman, TM; Bouloc, N; Buxton, RS; Chugh, J; Lougheed, KE; Osborne, SA; Saxty, B; Smerdon, SJ; Taylor, DL; Whalley, D Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis. Bioorg Med Chem Lett22:3349-53 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase PknB |
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Name: | Serine/threonine-protein kinase PknB |
Synonyms: | PKNB_MYCTU | pknB |
Type: | PROTEIN |
Mol. Mass.: | 66497.93 |
Organism: | Mycobacterium tuberculosis |
Description: | ChEMBL_774233 |
Residue: | 626 |
Sequence: | MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRREA
QNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIA
DACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTA
QYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARH
EGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEPPEAPKVLTDAERTSLLSSA
AGNLSGPRTDPLPRQDLDDTDRDRSIGSVGRWVAVVAVLAVLTVVVTIAINTFGGITRDV
QVPDVRGQSSADAIATLQNRGFKIRTLQKPDSTIPPDHVIGTDPAANTSVSAGDEITVNV
STGPEQREIPDVSTLTYAEAVKKLTAAGFGRFKQANSPSTPELVGKVIGTNPPANQTSAI
TNVVIIIVGSGPATKDIPDVAGQTVDVAQKNLNVYGFTKFSQASVDSPRPAGEVTGTNPP
AGTTVPVDSVIELQVSKGNQFVMPDLSGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQH
NRVVYQNPPAGTGVNRDGIITLRFGQ
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BDBM50381133 |
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n/a |
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Name | BDBM50381133 |
Synonyms: | CHEMBL2017734 |
Type | Small organic molecule |
Emp. Form. | C23H26N8 |
Mol. Mass. | 414.5061 |
SMILES | CN(C)[C@@H]1CCN(C1)c1cc(Nc2cc(n[nH]2)C2CC2)nc(n1)-c1cccc(c1)C#N |r| |
Structure |
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