Reaction Details |
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Target | C-C chemokine receptor type 2 |
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Ligand | BDBM50219887 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_814289 (CHEMBL2019386) |
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IC50 | 2200±n/a nM |
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Citation | Carter, PH; Brown, GD; King, SR; Voss, ME; Tebben, AJ; Cherney, RJ; Mandlekar, S; Lo, YC; Yang, G; Miller, PB; Scherle, PA; Zhao, Q; Decicco, CP Discovery of an orally-bioavailable CC Chemokine Receptor 2 antagonist derived from an acyclic diaminoalcohol backbone. Bioorg Med Chem Lett22:3311-6 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-C chemokine receptor type 2 |
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Name: | C-C chemokine receptor type 2 |
Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
Type: | Enzyme |
Mol. Mass.: | 41932.32 |
Organism: | Homo sapiens (Human) |
Description: | P41597 |
Residue: | 374 |
Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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BDBM50219887 |
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n/a |
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Name | BDBM50219887 |
Synonyms: | (R)-N-(2-(3-(2,4-dimethylbenzylamino)-1-hydroxypropan-2-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide | CHEMBL399328 |
Type | Small organic molecule |
Emp. Form. | C22H26F3N3O3 |
Mol. Mass. | 437.4553 |
SMILES | Cc1ccc(CNC[C@H](CO)NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)c(C)c1 |
Structure |
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