| Reaction Details |
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 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 5B |
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| Ligand | BDBM50382462 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_815758 (CHEMBL2025842) |
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| Ki | 10100±n/a nM |
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| Citation |  Page, BD; Khoury, H; Laister, RC; Fletcher, S; Vellozo, M; Manzoli, A; Yue, P; Turkson, J; Minden, MD; Gunning, PT Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity. J Med Chem55:1047-55 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Signal transducer and activator of transcription 5B |
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| Name: | Signal transducer and activator of transcription 5B |
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| Synonyms: | STA5B_HUMAN | STAT5B | Signal transducer and activator of transcription 5B | Transcription factor STAT5b (STAT5b) |
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| Type: | Protein |
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| Mol. Mass.: | 89858.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 787 |
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| Sequence: | MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL
LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV
REANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
RIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
NVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMS
LKRIKRSDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATA
TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
SSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNK
QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRL
GDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGG
GSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQ
WIPHAQS
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| BDBM50382462 |
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| n/a |
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| Name | BDBM50382462 |
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| Synonyms: | CHEMBL2023988 | US10196373, Compound 27KI |
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| Type | Small organic molecule |
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| Emp. Form. | C36H38N4O7S |
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| Mol. Mass. | 670.775 |
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| SMILES | CN(CC(=O)N(Cc1ccc(cc1)C1CCN(CC1)c1ccc(cc1)C(N)=O)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1ccc(C)cc1 |
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| Structure | 
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