| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 3 |
|---|
| Ligand | BDBM50382460 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_815757 (CHEMBL2025841) |
|---|
| Ki | 2800±n/a nM |
|---|
| Citation |  Page, BD; Khoury, H; Laister, RC; Fletcher, S; Vellozo, M; Manzoli, A; Yue, P; Turkson, J; Minden, MD; Gunning, PT Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity. J Med Chem55:1047-55 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Signal transducer and activator of transcription 3 |
|---|
| Name: | Signal transducer and activator of transcription 3 |
|---|
| Synonyms: | APRF | STAT3 | STAT3_HUMAN | Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 88064.31 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P40763 |
|---|
| Residue: | 770 |
|---|
| Sequence: | MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
|
|
|
|---|
| BDBM50382460 |
|---|
| n/a |
|---|
| Name | BDBM50382460 |
|---|
| Synonyms: | CHEMBL2023985 | US10196373, Compound 27NA |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C38H34N2O8S |
|---|
| Mol. Mass. | 678.75 |
|---|
| SMILES | COC(=O)c1cccc(c1)-c1ccc(cc1)-c1ccc(CN(C(=O)CN(C)S(=O)(=O)c2ccc(C)cc2)c2ccc(C(O)=O)c(O)c2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
