Reaction Details |
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Target | Signal transducer and activator of transcription 1-alpha/beta |
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Ligand | BDBM50353435 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_815759 (CHEMBL2025843) |
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Ki | 22000±n/a nM |
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Citation | Page, BD; Khoury, H; Laister, RC; Fletcher, S; Vellozo, M; Manzoli, A; Yue, P; Turkson, J; Minden, MD; Gunning, PT Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity. J Med Chem55:1047-55 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Signal transducer and activator of transcription 1-alpha/beta |
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Name: | Signal transducer and activator of transcription 1-alpha/beta |
Synonyms: | STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha |
Type: | Cytosolic Transcription Factor |
Mol. Mass.: | 87327.69 |
Organism: | Homo sapiens (Human) |
Description: | Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA. |
Residue: | 750 |
Sequence: | MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL
LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ
RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR
EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK
RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV
LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV
KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN
EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE
PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT
RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL
LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP
ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT
DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
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BDBM50353435 |
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n/a |
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Name | BDBM50353435 |
Synonyms: | CHEMBL1829874 | US10196373, Compound 45K |
Type | Small organic molecule |
Emp. Form. | C29H31ClN2O6S |
Mol. Mass. | 571.084 |
SMILES | CN(CC(=O)N(Cc1ccc(cc1)C1CCCCC1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1ccc(Cl)cc1 |
Structure |
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