| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calcitonin gene-related peptide type 1 receptor |
|---|
| Ligand | BDBM50382796 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_815265 (CHEMBL2025456) |
|---|
| IC50 | 0.21±n/a nM |
|---|
| Citation |  Luo, G; Chen, L; Civiello, R; Pin, SS; Xu, C; Kostich, W; Kelley, M; Conway, CM; Macor, JE; Dubowchik, GM Calcitonin gene-related peptide (CGRP) receptor antagonists: pyridine as a replacement for a core amide group. Bioorg Med Chem Lett22:2917-21 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calcitonin gene-related peptide type 1 receptor |
|---|
| Name: | Calcitonin gene-related peptide type 1 receptor |
|---|
| Synonyms: | Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 52980.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16602 |
|---|
| Residue: | 461 |
|---|
| Sequence: | MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
|
|
|
|---|
| BDBM50382796 |
|---|
| n/a |
|---|
| Name | BDBM50382796 |
|---|
| Synonyms: | CHEMBL2024603 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H30N6O4 |
|---|
| Mol. Mass. | 538.597 |
|---|
| SMILES | Cc1cc(CC(OC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)c2cc(C=O)ccn2)cc2cn[nH]c12 |
|---|
| Structure | 
|
|---|
Search and Browse
