| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
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| Ligand | BDBM50382801 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_817927 (CHEMBL2027575) |
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| IC50 | >10000±n/a nM |
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| Citation |  Blanchard, S; Soh, CK; Lee, CP; Poulsen, A; Bonday, Z; Goh, KL; Goh, KC; Goh, MK; Pasha, MK; Wang, H; Williams, M; Wood, JM; Ethirajulu, K; Dymock, BW 2-anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1. Bioorg Med Chem Lett22:2880-4 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 2 |
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| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| BDBM50382801 |
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| n/a |
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| Name | BDBM50382801 |
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| Synonyms: | CHEMBL2023415 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28N8O3 |
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| Mol. Mass. | 488.5416 |
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| SMILES | COc1ccc(cc1)-c1nc(Nc2cccc(NC(=O)NCCN3CCOCC3)c2)nc2nc[nH]c12 |
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| Structure | 
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