| Reaction Details |
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 | Report a problem with these data |
| Target | Kinesin heavy chain isoform 5A |
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| Ligand | BDBM50383087 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_818702 (CHEMBL2033191) |
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| IC50 | 50000±n/a nM |
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| Citation |  Nagarajan, S; Skoufias, DA; Kozielski, F; Pae, AN Receptor-ligand interaction-based virtual screening for novel Eg5/kinesin spindle protein inhibitors. J Med Chem55:2561-73 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kinesin heavy chain isoform 5A |
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| Name: | Kinesin heavy chain isoform 5A |
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| Synonyms: | KIF5A | KIF5A_HUMAN | NKHC1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 117363.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_818702 |
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| Residue: | 1032 |
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| Sequence: | MAETNNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVVIGGKPYVFDRVFPPNTTQE
QVYHACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHI
YSMDENLEFHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEI
LDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQENMETEQKLSGKLYLVDLAGSEKVS
KTGAEGAVLDEAKNINKSLSALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTM
FICCSPSSYNDAETKSTLMFGQRAKTIKNTASVNLELTAEQWKKKYEKEKEKTKAQKETI
AKLEAELSRWRNGENVPETERLAGEEAALGAELCEETPVNDNSSIVVRIAPEERQKYEEE
IRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAA
KDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELSQKVATMLSLESELQRLQEVS
GHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSEVKS
VVKRCRQLENLQVECHRKMEVTGRELSSCQLLISQHEAKIRSLTEYMQSVELKKRHLEES
YDSLSDELAKLQAQETVHEVALKDKEPDTQDADEVKKALELQMESHREAHHRQLARLRDE
INEKQKTIDELKDLNQKLQLELEKLQADYEKLKSEEHEKSTKLQELTFLYERHEQSKQDL
KGLEETVARELQTLHNLRKLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQL
TKVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDRI
KEAVRYKSSGKRGHSAQIAKPVRPGHYPASSPTNPYGTRSPECISYTNSLFQNYQNLYLQ
ATPSSTSDMYFANSCTSSGATSSGGPLASYQKANMDNGNATDINDNRSDLPCGYEAEDQA
KLFPLHQETAAS
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| BDBM50383087 |
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| n/a |
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| Name | BDBM50383087 |
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| Synonyms: | CHEMBL2031572 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15F2N5O2 |
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| Mol. Mass. | 395.3622 |
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| SMILES | Cc1ccc(cc1C)-n1c2nc(nc(C(N)=O)c2[nH]c1=O)-c1ccc(F)cc1F |
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| Structure | 
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