| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor subfamily 1 group D member 1 |
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| Ligand | BDBM50383675 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_819010 (CHEMBL2034242) |
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| EC50 | 77±n/a nM |
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| Citation |  Noel, R; Song, X; Shin, Y; Banerjee, S; Kojetin, D; Lin, L; Ruiz, CH; Cameron, MD; Burris, TP; Kamenecka, TM Synthesis and SAR of tetrahydroisoquinolines as Rev-erba agonists. Bioorg Med Chem Lett22:3739-42 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor subfamily 1 group D member 1 |
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| Name: | Nuclear receptor subfamily 1 group D member 1 |
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| Synonyms: | EAR-1 | EAR1 | HREV | NR1D1 | NR1D1_HUMAN | Rev-erbA-alpha | THRAL | V-erbA-related protein 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66822.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_958222 |
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| Residue: | 614 |
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| Sequence: | MTTLDSNNNTGGVITYIGSSGSSPSRTSPESLYSDNSNGSFQSLTQGCPTYFPPSPTGSL
TQDPARSFGSIPPSLSDDGSPSSSSSSSSSSSSFYNGSPPGSLQVAMEDSSRVSPSKSTS
NITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRI
NRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSAMNLANNQLSSQCPLETS
PTQHPTPGPMGPSPPPAPVPSPLVGFSQFPQQLTPPRSPSPEPTVEDVISQVARAHREIF
TYAHDKLGSSPGNFNANHASGSPPATTPHRWENQGCPPAPNDNNTLAAQRHNEALNGLRQ
APSSYPPTWPPGPAHHSCHQSNSNGHRLCPTHVYAAPEGKAPANSPRQGNSKNVLLACPM
NMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVL
MVRFASLFNVKDQTVMFLSRTTYSLQELGAMGMGDLLSAMFDFSEKLNSLALTEEELGLF
TAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNRPLETSRFTKLLLKLPDLRTLNN
MHSEKLLSFRVDAQ
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| BDBM50383675 |
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| n/a |
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| Name | BDBM50383675 |
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| Synonyms: | CHEMBL2030074 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H29NO3 |
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| Mol. Mass. | 451.5562 |
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| SMILES | CCCOc1ccc(OCC2Cc3ccccc3CN2C(=O)c2cccc3ccccc23)cc1 |
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| Structure | 
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