| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cGMP-specific 3',5'-cyclic phosphodiesterase |
|---|
| Ligand | BDBM50384241 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_820074 (CHEMBL2032847) |
|---|
| IC50 | 6000±n/a nM |
|---|
| Citation |  Nam, KY; Choi, NS; Han, CK; Ahn, SK Identification of chalcones as potent and selective PDE5A1 inhibitors. Bioorg Med Chem Lett22:3983-7 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cGMP-specific 3',5'-cyclic phosphodiesterase |
|---|
| Name: | cGMP-specific 3',5'-cyclic phosphodiesterase |
|---|
| Synonyms: | PDE5 | PDE5A | PDE5A_BOVIN | Phosphodiesterase 5A |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 98615.45 |
|---|
| Organism: | Bos taurus |
|---|
| Description: | ChEMBL_155186 |
|---|
| Residue: | 865 |
|---|
| Sequence: | MERAGPGSARPQQQWDQDSVEAWLDDHWDFTFSYFVRKGTREMVNAWFAERVHTIPVCKE
GIKGHTESCSCPLQPSPRAESSVPGTPTRKISASEFDRPLRPIVIKDSEGTVSFLSDSDK
KEQMPLTSPRFDNDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLV
CEDSSNDKFLISRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAAFGEPLNIKDAYEDPR
FNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFC
GIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIF
IVDEDCSDSFSSVFHMECEELEKSSDTLTRERDANRINYMYAQYVKNTMEPLNIPDVSKD
KRFPWTNENMGNINQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEETTGKVKAFNRNDEQ
FLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPS
AQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCKWILSVKKNYRKNV
AYHNWRHAFNTAQCMFAALKAGKIQKRLTDLEILALLIAALSHDLDHRGVNNSYIQRSEH
PLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIK
RRGEFFELIMKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQG
DRERKELNIEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNR
QKWQALAEQQEKTLINGESSQTKRN
|
|
|
|---|
| BDBM50384241 |
|---|
| n/a |
|---|
| Name | BDBM50384241 |
|---|
| Synonyms: | CHEMBL2030203 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H20O5 |
|---|
| Mol. Mass. | 328.3591 |
|---|
| SMILES | COc1ccc(C(=O)\C=C\c2cc(OC)ccc2OC)c(OC)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
