Reaction Details |
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Target | Orexin/Hypocretin receptor type 1 |
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Ligand | BDBM50384412 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_818372 (CHEMBL2034509) |
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IC50 | 0.8±n/a nM |
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Citation | Jiang, R; Song, X; Bali, P; Smith, A; Bayona, CR; Lin, L; Cameron, MD; McDonald, PH; Kenny, PJ; Kamenecka, TM Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists. Bioorg Med Chem Lett22:3890-4 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Orexin/Hypocretin receptor type 1 |
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Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
Type: | Protein |
Mol. Mass.: | 47554.50 |
Organism: | Homo sapiens (Human) |
Description: | O43613 |
Residue: | 425 |
Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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BDBM50384412 |
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n/a |
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Name | BDBM50384412 |
Synonyms: | CHEMBL2031504 |
Type | Small organic molecule |
Emp. Form. | C27H26FN3O3S |
Mol. Mass. | 491.577 |
SMILES | C[C@H]1CCC[C@@H](CNC(=O)c2cccc3occc23)N1C(=O)c1nc(C)sc1-c1ccc(F)cc1 |r| |
Structure |
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