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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cytochrome P450 2D6 | ||
| Ligand | BDBM50384877 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_821299 (CHEMBL2040129) | ||
| IC50 | >10000±n/a nM | ||
| Citation |  William, AD; Lee, AC; Poulsen, A; Goh, KC; Madan, B; Hart, S; Tan, E; Wang, H; Nagaraj, H; Chen, D; Lee, CP; Sun, ET; Jayaraman, R; Pasha, MK; Ethirajulu, K; Wood, JM; Dymock, BW Discovery of the macrocycle (9E)-15-(2-(pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a potent inhibitor of janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) for the treatment of rheumatoid arth J Med Chem55:2623-40 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cytochrome P450 2D6 | |||
| Name: | Cytochrome P450 2D6 | ||
| Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 55774.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P10635 | ||
| Residue: | 497 | ||
| Sequence: |
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| BDBM50384877 | |||
| n/a | |||
| Name | BDBM50384877 | ||
| Synonyms: | CHEMBL2035183 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H30N4O3S | ||
| Mol. Mass. | 478.606 | ||
| SMILES | C(CN1CCCC1)Oc1ccc2Nc3nccc(n3)-c3ccc(COC\C=C\COCc1c2)s3 |t:28| | ||
| Structure | 
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