Reaction Details |
| Report a problem with these data |
Target | Thyroid hormone receptor alpha |
---|
Ligand | BDBM50385110 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_821530 (CHEMBL2038198) |
---|
Ki | 300±n/a nM |
---|
Citation | Shiohara, H; Nakamura, T; Kikuchi, N; Ozawa, T; Nagano, R; Matsuzawa, A; Ohnota, H; Miyamoto, T; Ichikawa, K; Hashizume, K Discovery of novel indane derivatives as liver-selective thyroid hormone receptorß (TRß) agonists for the treatment of dyslipidemia. Bioorg Med Chem20:3622-34 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Thyroid hormone receptor alpha |
---|
Name: | Thyroid hormone receptor alpha |
Synonyms: | C-erbA-alpha | EAR-7 | EAR7 | ERBA1 | NR1A1 | Nuclear receptor subfamily 1 group A member 1 | THA_HUMAN | THRA | THRA1 | THRA2 | Thyroid Hormone Receptor (TR-alpha) | Thyroid hormone receptor | Thyroid hormone receptor alpha | Thyroid hormone receptor apha | c-erbA-1 |
Type: | Receptor |
Mol. Mass.: | 54818.00 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRalpha 1. |
Residue: | 490 |
Sequence: | MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA
TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL
GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC
EDLAGNAASP
|
|
|
BDBM50385110 |
---|
n/a |
---|
Name | BDBM50385110 |
Synonyms: | CHEMBL2035880 |
Type | Small organic molecule |
Emp. Form. | C22H24BrNO5 |
Mol. Mass. | 462.334 |
SMILES | CC(C)c1cc(Oc2c(Br)cc(NC(=O)CC(O)=O)c3CCCCc23)ccc1O |
Structure |
|